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Proteins are essential for every living cell, participating in all cellular processes. The knowledge of their structure and function enables understanding the cell and living organisms’ functioning. Our group studies proteins by analyzing the relationships between their structures and functions and their possible metabolic roles in […]
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The laboratory of Physiology and Genetics of Actinomycetes carries out various lines of work related to: 1) the use of genetic engineering, metabolic engineering and synthetic biology techniques for the production of new lipidic molecules with novel physicochemical properties using Escherichia coli as a platform of […]
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The research activities carried out in our lab cover three main areas of interest: the characterization of metalo-β-lactamases(MβLs), which are zinc enzymes involved in the resistance displayed by some pathogenic bacteria to β-lactam antibiotics, the characterization of copper proteins involved in cellular respiration, and the characterization […]
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Most cellular functions come as a result of the interplay of a huge number of differential interactions between macromolecules and ligands, which define what has been termed the “interactome”. The nature of each interaction may be essential for a number of biological processes ranging from the […]
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The research we carry out falls within a priority area: the study of antibiotic resistance mechanisms and the development of strategies to counteract them. The rapid development of antibiotic resistance represents a great challenge for the prevention and treatment of bacterial infections. It is critical to […]
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The structure and function of proteins depend on multiple factors such as sub-celullar localization, post-translational modifications and interactions with other biomolecules. However, most protein structural and mechanistic studies are typically performed on isolated samples, under conditions that differ substantially from in vivo environments of live cells. […]
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We study the three-dimensional structure of essential components of living matter in order to arrive at an atomic resolution understanding of the architecture and molecular mechanisms of life. We focus on the investigation of the molecular bases of the activity of proteins relevant to bacterial fitness, […]
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The bacterial cell envelope, a complex multilayered structure, plays a crucial role in cell growth and survival by ensuring cellular integrity, serving as a protective barrier to control permeability, and mediating interactions with the environment. In Gram-positive bacteria, the cell envelope comprises the plasma membrane and […]