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Lipids have structural and cell signaling functions. In our laboratory we study the mechanisms that coordinate the synthesis of phospholipids and their role as signal molecules during cell differentiation processes; focusing on the differentiation of neural stem cells. Knowledge of these processes is of great importance […]
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The laboratory of Physiology and Genetics of Actinomycetes carries out various lines of work related to: 1) the use of genetic engineering, metabolic engineering and synthetic biology techniques for the production of new lipidic molecules with novel physicochemical properties using Escherichia coli as a platform of […]
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The research activities carried out in our lab cover three main areas of interest: the characterization of metalo-β-lactamases(MβLs), which are zinc enzymes involved in the resistance displayed by some pathogenic bacteria to β-lactam antibiotics, the characterization of copper proteins involved in cellular respiration, and the characterization […]
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The evolution of bacterial resistance to antimicrobials poses nowadays a major thread to global human health and food security. In our group we are interested in revealing the molecular basis of the resistance mechanisms to last generation beta-lactam antibiotics, in particular the carbapenems, and the evolution […]
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Lipids are the major components of biological membranes, fulfilling structural functions, energy storage and intra-and intercellular signaling. Comprise a large group of compounds including fatty acids, sphingolipids and sterols glycerolipids, among others. Our laboratory is focused, from different perspectives, to the study of biochemistry and molecular […]
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We perform molecular epidemiology studies to identify and characterize novel viruses in human and animal hosts of Argentina in accordance with the One Health guidelines, an international initiative that promotes the interdependence between human and animal health, and its link with the environment. For this, we […]
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Our laboratory studies the role of fatty acid synthesis and enzyme cofactors in the cell biology and physiology of microorganisms and animals. The implications of this topic extend from the search for antimicrobials that act by interfering with fatty acid synthesis and derived metabolites, to the […]
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The research we carry out falls within a priority area: the study of antibiotic resistance mechanisms and the development of strategies to counteract them. The rapid development of antibiotic resistance represents a great challenge for the prevention and treatment of bacterial infections. It is critical to […]
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Our work aims at the multifactorial study of cellular physiological parameters that help to interpret and understand intracellular signaling pathways from the point of view of systemic biology. To reach this goal, we use different tools that allow the reading of multiple intracellular factors. Our group […]
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The structure and function of proteins depend on multiple factors such as sub-celullar localization, post-translational modifications and interactions with other biomolecules. However, most protein structural and mechanistic studies are typically performed on isolated samples, under conditions that differ substantially from in vivo environments of live cells. […]