research groups

Molecular and Cell Biology of Lipids

summary

Lipids have structural and cell signaling functions. In our laboratory we study the mechanisms that coordinate the synthesis of phospholipids and their role as signal molecules during cell differentiation processes; focusing on the differentiation of neural stem cells. Knowledge of these processes is of great importance from the physiological point of view, since it allows us to understand molecular and regulatory mechanisms associated with neuronal differentiation and, from them, identify targets for the development of preventive or regenerative therapeutic strategies for nervous tissue.
GROUP DIRECTOR
Banchio, Claudia

Sede:

CCT

Email:

banchio@ibr-conicet.gov.ar
Project Directors
Associated researchers
  • Robert, Maria Celeste
PhD POST-Fellows
PhD Fellows
  • Diaz Reyes, Mercyleidi
  • Donsanti, Catalina
  • Magaquian, Darío
Undergraduate Students
technicians

RESEARCH LINES

Phospholipids and its role during neuronal differentiation

It is well known that lipids, and specifically phospholipids, play structural roles in eukaryotic animal cells. However, in addition to this essential role, phospholipids fulfill regulatory and signaling functions.

In our laboratory, we are interested in investigating lipid-mediated regulatory processes that are associated with cell differentiation, using neural stem cell differentiation as a model.

We have shown that phosphatidylcholine increases neurogenesis and that phosphatidylethanolamine increases neural stem cell astrogliogenesis by changing the fate of neural precursors.

With these results, we propose to analyze the underlying mechanisms, evaluate their role of phospholipids under damage conditions (models of neurodegenerative diseases), and find their physiological reservoir.

These results will be key to understanding basic regulatory mechanisms associated with the differentiation of neural stem cells, which can be used for the rational design of regenerative strategies.

Images of our research lines

PUBLICATIONS AND PATENTS

Sphingosine 1-Phosphate Prevents Human Embryonic Stem Cell Death Following Ischemic Injury

European J of Lipid Science and Technology. 124(7), Assis, J., Fernandes, Aniceto B, Pompeu, P., Banchio C., Girardini J., Vieyra, A., Valcerde, R., Einicker-Lamas M. (2022)

Sphingosine 1-Phosphate Prevents Human Embryonic Stem Cell Death Following Ischemic Injury

European J of Lipid Science and Technology. 124(7), Assis, J., Fernandes, Aniceto B, Pompeu, P., Banchio C., Girardini J., Vieyra, A., Valcerde, R., Einicker-Lamas M. (2022)
DOI

Phosphatidylcholine restores neuronal plasticity of neural stem cells under inflammatory stress.

Sci Rep 24;11(1):22891. Magaquian, D.,Delgado,S. Perez. C, and Banchio C. (2021).

Phosphatidylcholine restores neuronal plasticity of neural stem cells under inflammatory stress.

Sci Rep 24;11(1):22891. Magaquian, D.,Delgado,S. Perez. C, and Banchio C. (2021).
DOI

KDM2B regulates choline kinase expression and neuronal differentiation of neuroblastoma cells.

PLoS One. 10;14(1) Domizi P, Malizia F, Chazarreta-Cifre L, Diacovich L, Banchio C.(2019). doi: 10.1371/journal.pone.0210207

KDM2B regulates choline kinase expression and neuronal differentiation of neuroblastoma cells.

PLoS One. 10;14(1) Domizi P, Malizia F, Chazarreta-Cifre L, Diacovich L, Banchio C.(2019). doi: 10.1371/journal.pone.0210207
DOI

Specific Phospholipids Regulate the Acquisition of Neuronal and Astroglial Identities in Post-Mitotic Cells.

Sci Rep 11;8(1):460. Montaner, A., da Silva Santana T., Schroeder T., Einiker- Lamas M, Girardini J, Costa M and Banchio, C.(2018). doi: 10.1038/s41598-017-18700-4.

Specific Phospholipids Regulate the Acquisition of Neuronal and Astroglial Identities in Post-Mitotic Cells.

Sci Rep 11;8(1):460. Montaner, A., da Silva Santana T., Schroeder T., Einiker- Lamas M, Girardini J, Costa M and Banchio, C.(2018). doi: 10.1038/s41598-017-18700-4.
DOI

Lisophosphatidylcholine drives neuroblast cell fate.

Mol Neurobiol. 53(9):6316-6331. Paoletti, L. Domizi, P, Marcucci, H., Montaner, A., Krapf D, Salvador G. and Banchio C*.(2016)

Lisophosphatidylcholine drives neuroblast cell fate.

Mol Neurobiol. 53(9):6316-6331. Paoletti, L. Domizi, P, Marcucci, H., Montaner, A., Krapf D, Salvador G. and Banchio C*.(2016)
DOI

contacto@conicet.gov.ar

Sede CCT Rosario

Ocampo y Esmeralda, Predio CONICET-Rosario
2000 Rosario, Santa Fe, Argentina
Tel. 54-341-4237070 / 4237500 / 4237200

Sede Facultad de Ciencias Bioquímicas y Farmacéuticas

Universidad Nacional de Rosario - Suipacha 531
2000 Rosario, Santa Fe, Argentina
Tel. +54 341 4350596 / 4350661 / 4351235

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