research groups
Molecular and Cell Biology of Lipids
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Phospholipids and its role during neuronal differentiation
It is well known that lipids, and specifically phospholipids, play structural roles in eukaryotic animal cells. However, in addition to this essential role, phospholipids fulfill regulatory and signaling functions.
In our laboratory, we are interested in investigating lipid-mediated regulatory processes that are associated with cell differentiation, using neural stem cell differentiation as a model.
We have shown that phosphatidylcholine increases neurogenesis and that phosphatidylethanolamine increases neural stem cell astrogliogenesis by changing the fate of neural precursors.
With these results, we propose to analyze the underlying mechanisms, evaluate their role of phospholipids under damage conditions (models of neurodegenerative diseases), and find their physiological reservoir.
These results will be key to understanding basic regulatory mechanisms associated with the differentiation of neural stem cells, which can be used for the rational design of regenerative strategies.
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PUBLICATIONS AND PATENTS
Sphingosine 1-Phosphate Prevents Human Embryonic Stem Cell Death Following Ischemic Injury
Sphingosine 1-Phosphate Prevents Human Embryonic Stem Cell Death Following Ischemic Injury
Phosphatidylcholine restores neuronal plasticity of neural stem cells under inflammatory stress.
Phosphatidylcholine restores neuronal plasticity of neural stem cells under inflammatory stress.
KDM2B regulates choline kinase expression and neuronal differentiation of neuroblastoma cells.
KDM2B regulates choline kinase expression and neuronal differentiation of neuroblastoma cells.
Specific Phospholipids Regulate the Acquisition of Neuronal and Astroglial Identities in Post-Mitotic Cells.
Specific Phospholipids Regulate the Acquisition of Neuronal and Astroglial Identities in Post-Mitotic Cells.
Lisophosphatidylcholine drives neuroblast cell fate.
Lisophosphatidylcholine drives neuroblast cell fate.
Sede CCT Rosario
Ocampo y Esmeralda, Predio CONICET-Rosario
2000 Rosario, Santa Fe, Argentina
Tel. 54-341-4237070 / 4237500 / 4237200
Sede Facultad de Ciencias Bioquímicas y Farmacéuticas
Universidad Nacional de Rosario - Suipacha 531
2000 Rosario, Santa Fe, Argentina
Tel. +54 341 4350596 / 4350661 / 4351235
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