Resumen:
The engineering of microbial production systems for high-value natural products relies heavily on the availability of computational tools. In this talk I will discuss some of the software we have developed to assist all steps of the design–build–test cycle of synthetic biology, including for example:
- New methods for the detection and analysis of biosynthetic gene clusters (antiSMASH, multiGeneBlast) and the identification of novel compounds (Pep2Path).
- Bespoke computational modelling approaches for metabolic networks to aid host cell optimization and pathway engineering (MultiMetEval, Uncertainty Modelling).
- Metabolomics analysis software for the evaluation and debugging of engineered microbes (MetAssign, mzMatch, mzMatch-ISO).
The talk will illustrate recent developments and applications of these tools in the context of synthetic biology.
